Article
Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2012
de Larrea Carlos Fernández, Navarro Alfons, Tejero Rut, Tovar Natalia, Díaz Tania, Cibeira María Teresa, Rosiñol Laura, Ferrer Gerardo, Rovira Montserrat, Rozman María, Monzó Mariano, Bladé Joan
Abstract excerpt
PURPOSE: A distinctive new group of polymorphisms is constituted by single-nucleotide polymorphism (SNP) in miRNA processing machinery in miRNA precursor molecules and in miRNA-binding sites, known as miRSNPs. The aim of this study was to ascertain the prognostic impact of six miRSNPs in patients with multiple myeloma and analyze the functional consequences. EXPERIMENTAL DESIGN: One hundred and thirty-seven...
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