Depressed patients in remission show an interaction between variance in the mineralocorticoid receptor NR3C2 gene and childhood trauma on negative memory bias.

doi:10.1097/YPG.0000000000000081

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Depressed patients in remission show an interaction between variance in the mineralocorticoid receptor NR3C2 gene and childhood trauma on negative memory bias.

Psychiatric genetics - 1 Jun 2015

Vrijsen Janna N, Vogel Susanne, Arias-Vásquez Alejandro, Franke Barbara, Fernández Guillén, Becker Eni S, Speckens Anne, van Oostrom Iris

Abstract excerpt

BACKGROUND: Genetic, environmental, and cognitive factors play a role in the development and recurrence of depression. More specifically, cognitive biases have been associated with depression risk genes and life events. Recently, the mineralocorticoid receptor NR3C2 gene, and in particular the rs5534 polymorphism, has been associated with negative memory bias, at least in healthy individuals who experienced...

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PMID: 25714450
DOI: 10.1097/YPG.0000000000000081

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