Article
Functional polymorphisms of the mineralocorticoid receptor gene NR3C2 are associated with diminished memory decline: Results from a longitudinal general-population study.
Molecular genetics & genomic medicine - 1 Sept 2020
Terock Jan, Van der Auwera Sandra, Janowitz Deborah, Wittfeld Katharina, Teumer Alexander, Grabe Hans J
Abstract excerpt
BACKGROUND: The mineralocorticoid receptor (MR) in the brain has a key role in the regulation of the central stress response and is associated with memory performance. We investigated whether the genetic polymorphisms rs5522 and rs2070951 of NR3C2 showed main and interactive effects with childhood trauma on memory decline. METHODS: Declarative memory was longitudinally assessed in 1,318 participants from the...
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