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Article

Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women.

Biological psychology - 1 Jan 2012

van Oostrom Iris, Franke Barbara, Rijpkema Mark, Gerritsen Lotte, Arias-Vásquez Alejandro, Fernández Guillèn, Tendolkar Indira

Abstract excerpt

Recent meta-analyses point towards a pathogenic role of the Val66Met variant of the brain-derived neurotrophic factor (BDNF) in major depressive disorder, specifically in males. We investigated whether BDNF Val66Met shows a male-specific interaction with childhood stressful life events on affective memory bias, a cognitive susceptibility factor for depression. Healthy volunteers (n=430; 272 females and 158 males)...

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Source

Identifiers

PMID: 22033217
DOI: 10.1016/j.biopsycho.2011.10.012

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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