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Article

Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1.

RNA (New York, N.Y.) - 1 Jun 2015

Schwer Beate, Ghosh Agnidipta, Sanchez Ana M, Lima Christopher D, Shuman Stewart

Abstract excerpt

Protein phosphatases regulate mRNA synthesis and processing by remodeling the carboxy-terminal domain (CTD) of RNA polymerase II (Pol2) to dynamically inscribe a Pol2 CTD code. Fission yeast Fcp1 (SpFcp1) is an essential 723-amino acid CTD phosphatase that preferentially hydrolyzes Ser2-PO4 of the YS(2)PTSPS repeat. The SpFcp1 catalytic domain (aa 140-580) is composed of a DxDxT acyl-phosphatase module (FCPH) and...

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Identifiers

PMID: 25883047
DOI: 10.1261/rna.050286.115
PMCID: PMC4436666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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