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Article

A novel role for Gemin5 in mRNA translation

9 Dec 2008

Abstract excerpt

In eukaryotic cells translation initiation occurs through two alternative mechanisms, a cap-dependent operating in the majority of mRNAs, and a 5'-end-independent driven by internal ribosome entry site (IRES) elements, specific for a subset of mRNAs. IRES elements recruit the translation machinery to an internal position in the mRNA through a mechanism involving the IRES structure and several trans-acting...

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PMID: 19066202
DOI: 10.1093/nar/gkn979

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