Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forks.

PLoS genetics - 1 Nov 2011

Clemente-Ruiz Marta, González-Prieto Román, Prado Félix

Abstract excerpt

Chromatin assembly mutants accumulate recombinogenic DNA damage and are sensitive to genotoxic agents. Here we have analyzed why impairment of the H3K56 acetylation-dependent CAF1 and Rtt106 chromatin assembly pathways, which have redundant roles in H3/H4 deposition during DNA replication, leads to genetic instability. We show that the absence of H3K56 acetylation or the simultaneous knock out of CAF1 and Rtt106...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Acetyltransferases

Share to Homologous Recombination

Share to Lysine

Share to Molecular Chaperones

Share to Nucleosomes

Share to Ribonucleases

Source

Open in PubMed Open full text

Identifiers

PMID: 22102830
DOI: 10.1371/journal.pgen.1002376
PMCID: PMC3213180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forks.PMID 22102830Read ↗

Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly.Semantic proximity Read ↗

Histone H3 lysine 56 acetylation and the response to DNA replication fork damage.Semantic proximity Read ↗

A role for Gcn5 in replication-coupled nucleosome assembly.Semantic proximity Read ↗

Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis.Semantic proximity Read ↗

The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly.Semantic proximity Read ↗

Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106.Semantic proximity Read ↗

Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins.Semantic proximity Read ↗

A negatively charged residue in place of histone H3K56 supports chromatin assembly factor association but not genotoxic stress resistance.Semantic proximity Read ↗

Histone chaperone Rtt106 promotes nucleosome formation using (H3-H4)2 tetramers.Semantic proximity Read ↗

Smc5/6 maintains stalled replication forks in a recombination-competent conformation.Semantic proximity Read ↗

A reversible histone H3 acetylation cooperates with mismatch repair and replicative polymerases in maintaining genome stability.Semantic proximity Read ↗

Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.