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Article

Mutation-Specific and Common Phosphotyrosine Signatures of KRAS G12D and G13D Alleles.

Journal of proteome research - 1 Jan 2021

Tahir Raiha, Renuse Santosh, Udainiya Savita, Madugundu Anil K, Cutler Jevon A, Nirujogi Raja Sekhar, Na Chan Hyun, Xu Yaoyu, Wu Xinyan, Pandey Akhilesh

Abstract excerpt

KRAS is one of the most frequently mutated genes across all cancer subtypes. Two of the most frequent oncogenic KRAS mutations observed in patients result in glycine to aspartic acid substitution at either codon 12 (G12D) or 13 (G13D). Although the biochemical differences between these two predominant mutations are not fully understood, distinct clinical features of the resulting tumors suggest involvement of...

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PMID: 32986951
DOI: 10.1021/acs.jproteome.0c00587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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