Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.

doi:10.1093/jnci/djr523

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Article

Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.

Journal of the National Cancer Institute - 8 Feb 2012

Ihle Nathan T, Byers Lauren A, Kim Edward S, Saintigny Pierre, Lee J Jack, Blumenschein George R, Tsao Anne, Liu Suyu, Larsen Jill E, Wang Jing, Diao Lixia, Coombes Kevin R, Chen Lu, Zhang Shuxing, Abdelmelek Mena F, Tang Ximing, Papadimitrakopoulou Vassiliki, Minna John D, Lippman Scott M, Hong Waun K, Herbst Roy S, Wistuba Ignacio I, Heymach John V, Powis Garth

Abstract excerpt

BACKGROUND: Mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) play a critical role in cancer cell growth and resistance to therapy. Most mutations occur at codons 12 and 13. In colorectal cancer, the presence of any mutant KRas amino acid substitution is a negative predictor of patient response to targeted therapy. However, in non-small cell lung cancer (NSCLC), the evidence that KRAS...

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PMID: 22247021
DOI: 10.1093/jnci/djr523
PMCID: PMC3274509

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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