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Article

Overexpressed vs mutated Kras in murine fibroblasts: a molecular phenotyping study.

British journal of cancer - 24 Feb 2009

Horsch M, Recktenwald C V, Schädler S, Hrabé de Angelis M, Seliger B, Beckers J

Abstract excerpt

Ras acts in signalling pathways regulating the activity of multiple cellular functions including cell proliferation, differentiation, and apoptosis. Amino-acid exchanges at position 12, 13, or 61 of the Kras gene convert the proto-oncogene into an activated oncogene. Until now, a direct comparison of genome-wide expression profiling studies of Kras overexpression and different Kras mutant forms in a single assay...

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Identifiers

PMID: 19190631
DOI: 10.1038/sj.bjc.6604882
PMCID: PMC2653730

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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