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Article

Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications

10 Feb 2016

Abstract excerpt

UNLABELLED: Obesity is an important risk factor for breast cancer (BC) in postmenopausal women; interlinked molecular mechanisms might be involved in the pathogenesis. Increased levels of estrogens due to aromatization of the adipose tissue, inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and prostaglandin E2, insulin resistance and hyperactivation of insulin-like growth factors pathways,...

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PMID: 26865587
DOI: 10.1634/theoncologist.2015-0351

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