Article
Assessment of Multifactor Gene-Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2016
Usset Joseph L, Raghavan Rama, Tyrer Jonathan P, McGuire Valerie, Sieh Weiva, Webb Penelope, Chang-Claude Jenny, Rudolph Anja, Anton-Culver Hoda, Berchuck Andrew, Brinton Louise, Cunningham Julie M, DeFazio Anna, Doherty Jennifer A, Edwards Robert P, Gayther Simon A, Gentry-Maharaj Aleksandra, Goodman Marc T, Høgdall Estrid, Jensen Allan, Johnatty Sharon E, Kiemeney Lambertus A, Kjaer Susanne K, Larson Melissa C, Lurie Galina, Massuger Leon, Menon Usha, Modugno Francesmary, Moysich Kirsten B, Ness Roberta B, Pike Malcolm C, Ramus Susan J, Rossing Mary Anne, Rothstein Joseph, Song Honglin, Thompson Pamela J, van den Berg David J, Vierkant Robert A, Wang-Gohrke Shan, Wentzensen Nicolas, Whittemore Alice S, Wilkens Lynne R, Wu Anna H, Yang Hannah, Pearce Celeste Leigh, Schildkraut Joellen M, Pharoah Paul, Goode Ellen L, Fridley Brooke L
Abstract excerpt
BACKGROUND: Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure and elevated estrogen levels are associated with obesity in postmenopausal women. Therefore, we hypothesized that gene-environment interactions related to hormone-related risk factors could differ between obese and non-obese women. METHODS: We considered interactions between 11,441 SNPs within 80 candidate genes related to...
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