Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs.

Biochimica et biophysica acta - 1 Sept 2015

Cappelletti Pamela, Piubelli Luciano, Murtas Giulia, Caldinelli Laura, Valentino Mattia, Molla Gianluca, Pollegioni Loredano, Sacchi Silvia

Abstract excerpt

In the brain, d-amino acid oxidase plays a key role in modulating the N-methyl-d-aspartate receptor (NMDAR) activation state, catalyzing the stereospecific degradation of the coagonist d-serine. A relationship between d-serine signaling deregulation, NMDAR dysfunction, and CNS diseases is presumed. Notably, the R199W substitution in human DAAO (hDAAO) was associated with familial amyotrophic lateral sclerosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flavin-Adenine Dinucleotide

Share to Kinetics

Share to Ligands

Share to Protein Conformation

Share to Structure-Activity Relationship

Share to Transfection

Source

Identifiers

PMID: 25701391
DOI: 10.1016/j.bbapap.2015.02.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs.PMID 25701391Read ↗

Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.Semantic proximity Read ↗

Structure-function relationships in human d-aspartate oxidase: characterisation of variants corresponding to known single nucleotide polymorphisms.Semantic proximity Read ↗

Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase.Semantic proximity Read ↗

Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility.Semantic proximity Read ↗

Characterization of E121K mutation of D-amino acid oxidase - Insights into mechanisms leading to amyotrophic lateral sclerosis.Semantic proximity Read ↗

d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain.Semantic proximity Read ↗

Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation.Semantic proximity Read ↗

The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.Semantic proximity Read ↗

Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine.Semantic proximity Read ↗

Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.Semantic proximity Read ↗

The Role of D-Amino Acids in Alzheimer’s DiseaseSemantic proximity Read ↗

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.