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Article

Structure-function relationships in human d-aspartate oxidase: characterisation of variants corresponding to known single nucleotide polymorphisms.

Biochimica et biophysica acta. Proteins and proteomics - 1 Sept 2017

Katane Masumi, Kanazawa Ryo, Kobayashi Risa, Oishi Megumi, Nakayama Kazuki, Saitoh Yasuaki, Miyamoto Tetsuya, Sekine Masae, Homma Hiroshi

Abstract excerpt

d-Aspartate oxidase (DDO) is a degradative enzyme that is stereospecific for the acidic amino acid d-aspartate, an endogenous agonist of the N-methyl-d-aspartate (NMDA) receptor. Dysregulation of NMDA receptor-mediated neurotransmission has been implicated in the onset of various neuropsychiatric disorders including schizophrenia and in chronic pain. Thus, appropriate regulation of the amount of d-aspartate is...

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PMID: 28629864
DOI: 10.1016/j.bbapap.2017.06.010

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DDO

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