Article
Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility.
FEBS letters - 1 Feb 2017
Sacchi Silvia, Cappelletti Pamela, Pirone Luciano, Smaldone Giovanni, Pedone Emilia, Pollegioni Loredano
Abstract excerpt
In the human brain, pLG72 interacts with the flavoenzyme d-amino acid oxidase (hDAAO), which is involved in catabolism of d-serine, a co-agonist of N-methyl-d-aspartate receptors (NMDAR). Here, we investigated the wild-type pLG72, the R30K variant associated with schizophrenia susceptibility, and the K62E variant. The protein conformation, oligomeric state, ligand-, and hDAAO-binding properties are only slightly...
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