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Article

PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer.

Cancer immunology research - 1 Jun 2015

Severson Jill J, Serracino Hilary S, Mateescu Valerica, Raeburn Christopher D, McIntyre Robert C, Sams Sharon B, Haugen Bryan R, French Jena D

Abstract excerpt

Regional metastatic differentiated thyroid cancer (mDTC) provides a unique model in which to study the tumor-immune interface. These lymph node metastases persist for years, generally without progression to distant metastases. Although the immune system likely impedes disease progression, it is unsuccessful in eliminating disease. Our previous studies revealed that programmed death-1 (PD-1)(+) T cells were...

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Identifiers

PMID: 25701326
DOI: 10.1158/2326-6066.CIR-14-0201
PMCID: PMC4457654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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