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Article

A 4 Gene-based Immune Signature Predicts Dedifferentiation and Immune Exhaustion in Thyroid Cancer.

The Journal of clinical endocrinology and metabolism - 13 Jul 2021

Li Cui-Wei, Shi Xiao, Ma Ben, Wang Yu-Long, Lu Zhong-Wu, Liao Tian, Wang Yu, Ji Qing-Hai, Wei Wen-Jun

Abstract excerpt

CONTEXT: The role of immune-related genes (IRGs) in thyroid cancer dedifferentiation and accompanying immune exhaustion remains largely unexplored. OBJECTIVE: To construct a significant IRG-based signature indicative of dedifferentiation and immune exhaustion in thyroid cancer. DESIGN AND SETTINGS: One exploratory cohort and 2 validation cohorts were used to identify stably dysregulated IRGs in dedifferentiated...

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PMID: 33656532
DOI: 10.1210/clinem/dgab132

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