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Immune-Checkpoint Blockade Opposes CD8+ T-cell Suppression in Human and Murine Cancer

6 Feb 2019

Abstract excerpt

Abstract Immune-checkpoint blockade enhances antitumor responses against cancers. One cancer type that is sensitive to checkpoint blockade is squamous cell carcinoma of the head and neck (SCCHN), which we use here to study limitations of this treatment modality. We observed that CD8+ tumor-infiltrating lymphocytes (TILs) in SCCHN and melanoma express excess immune checkpoints components PD-1 and Tim-3 and are...

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PMID: 30728151
DOI: 10.1158/2326-6066.cir-18-0054

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