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Article

Detection and characterization of a novel subset of CD8⁺CD57⁺ T cells in metastatic melanoma with an incompletely differentiated phenotype.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2012

Wu Richard C, Liu Shujuan, Chacon Jessica A, Wu Sheng, Li Yufeng, Sukhumalchandra Pariya, Murray James L, Molldrem Jeffrey J, Hwu Patrick, Pircher Hanspeter, Lizée Gregory, Radvanyi Laszlo G

Abstract excerpt

PURPOSE: Tumor-specific T cells are frequently induced naturally in melanoma patients and infiltrate tumors. It is enigmatic why these patients fail to experience tumor regression. Given that CD8(+) T cells mediate antigen-specific killing of tumor cells, the focus of this study was to identify alterations in the differentiation of CD8(+) residing at the tumor site, with emphasis on a population expressing CD57,...

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Share to CD57 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocytes, Tumor-Infiltrating

Share to Receptors, Antigen, T-Cell

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Share to T-Lymphocytes, Cytotoxic

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Share to Tumor Necrosis Factor Receptor Superfamily, Member 7

Source

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Identifiers

PMID: 22307139
DOI: 10.1158/1078-0432.CCR-11-2034
PMCID: PMC3343210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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