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Article

PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma.

Journal for immunotherapy of cancer - 29 Nov 2019

Ma Jiaqiang, Zheng Bohao, Goswami Shyamal, Meng Lu, Zhang Dandan, Cao Chunmei, Li Teng, Zhu Fangming, Ma Lijie, Zhang Zhao, Zhang Shuhao, Duan Meng, Chen Qin, Gao Qiang, Zhang Xiaoming

Abstract excerpt

BACKGROUND: CD8+ T cells differentiate into exhausted status within tumors, including hepatocellular carcinoma (HCC), which constitutes a solid barrier to effective anti-tumor immunity. A detailed characterization of exhausted T cells and their prognostic value in HCC is lacking. METHODS: We collected fresh tumor tissues with adjacent non-tumor liver tissues and blood specimens of 56 HCC patients, as well as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31783783
DOI: 10.1186/s40425-019-0814-7
PMCID: PMC6884778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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