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From Tpex to Tex: a journey through CD8+ T cell responses in cancer immunotherapy

4 Sept 2023

Abstract excerpt

In a recent study published in Cell , Rahim et al. show that a subset of progenitor exhausted CD8 + T cells (Tpex) in uninvolved, regional lymph nodes (uiLNs) are clonally related to exhausted CD8 + T cells (Tex) in tumors of patients with head and neck squamous cell carcinoma (HNSCC) and following adjuvant immune checkpoint blockade (ICB) these clones expanded in the tumor suggestive of migration from the uiLNs...

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PMID: 37666801
DOI: 10.1038/s41392-023-01595-1

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