PD-1 and BTLA and CD8⁺T-cell “exhaustion” in cancer

Abstract excerpt

The elevated expression of PD-1, BTLA, and other co-inhibitory molecules on T cells from cancer patients has become an accepted signature for a state called T-cell "exhaustion" that has emerged almost as dogma in the field. However, here we propose that in some cases this "exhausted" T-cell phenotype may instead be an indicator of T cells that are in a more heightened state of T-cell activation more susceptible...

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