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Article

Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.

Cancer cell - 1 Apr 2007

Wu Rong, Hendrix-Lucas Neali, Kuick Rork, Zhai Yali, Schwartz Donald R, Akyol Aytekin, Hanash Samir, Misek David E, Katabuchi Hidetaka, Williams Bart O, Fearon Eric R, Cho Kathleen R

Abstract excerpt

One histologic subtype of ovarian carcinoma, ovarian endometrioid adenocarcinoma (OEA), frequently harbors mutations that constitutively activate Wnt/beta-catenin-dependent signaling. We now show that defects in the PI3K/Pten and Wnt/beta-catenin signaling pathways often occur together in a subset of human OEAs, suggesting their cooperation during OEA pathogenesis. Deregulation of these two pathways in the murine...

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Identifiers

PMID: 17418409
DOI: 10.1016/j.ccr.2007.02.016

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