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Article

Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation.

Oncotarget - 17 Jan 2017

Karlsson Thomas, Krakstad Camilla, Tangen Ingvild Løberg, Hoivik Erling A, Pollock Pamela M, Salvesen Helga B, Lewis Aurélia E

Abstract excerpt

PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β (encoded by PIK3CB) activity but little is known about this contribution in endometrial tumorigenesis. In this study, we find that p110β is overexpressed in a panel of 7 endometrial cancer cell...

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Identifiers

PMID: 28002804
DOI: 10.18632/oncotarget.13989
PMCID: PMC5354802

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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