Article
Familiality and SNP heritability of age at onset and episodicity in major depressive disorder.
Psychological medicine - 1 Jul 2015
Ferentinos P, Koukounari A, Power R, Rivera M, Uher R, Craddock N, Owen M J, Korszun A, Jones L, Jones I, Gill M, Rice J P, Ising M, Maier W, Mors O, Rietschel M, Preisig M, Binder E B, Aitchison K J, Mendlewicz J, Souery D, Hauser J, Henigsberg N, Breen G, Craig I W, Farmer A E, Müller-Myhsok B, McGuffin P, Lewis C M
Abstract excerpt
BACKGROUND: Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on whether these subphenotypes are familial or heritable is scarce. The aims of this study are to investigate the familiality of AAO and episode frequency in MDD and to assess the proportion of their...
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