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Article

Heritability of major depressive and comorbid anxiety disorders in multi-generational families at high risk for depression.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2016

Guffanti Guia, Gameroff Marc J, Warner Virginia, Talati Ardesheer, Glatt Charles E, Wickramaratne Priya, Weissman Myrna M

Abstract excerpt

Family studies have shown that MDD is highly transmittable but have not studied its heritability. Twin studies show heritability of about 40% and do not include anxiety disorders. We assessed heritability of MDD and comorbid anxiety disorders in a multigenerational study of family members at high risk for MDD. In addition, we tested the hypothesis that examined clinical subtypes of MDD defined by early and late...

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Source

Identifiers

PMID: 27452917
DOI: 10.1002/ajmg.b.32477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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