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Article

NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.

The Journal of biological chemistry - 10 Apr 2015

Stanicka Joanna, Russell Eileen G, Woolley John F, Cotter Thomas G

Abstract excerpt

Internal tandem duplication of the FMS-like tyrosine kinase (FLT3-ITD) receptor is present in 20% of acute myeloid leukemia (AML) patients and it has been associated with an aggressive AML phenotype. FLT3-ITD expressing cell lines have been shown to generate increased levels of reactive oxygen species (ROS) and DNA double strand breaks (DSBs). However, the molecular basis of how FLT3-ITD-driven ROS leads to the...

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Identifiers

PMID: 25697362
DOI: 10.1074/jbc.M113.510495
PMCID: PMC4392242

Genes

FLT3
NOX4

Provenance

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