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Article

Mutations in chronic lymphocytic leukemia and how they affect therapy choice: focus on NOTCH1, SF3B1, and TP53.

Hematology. American Society of Hematology. Education Program - 5 Dec 2014

Zent Clive S, Burack W Richard

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is characterized by a relatively small number of recurrent genetic defects. These can be evaluated by clinically available methods such as fluorescent in situ hybridization and targeted sequencing approaches to provide data that can be very helpful in prognostication and planning of treatment. Acquired defects in the p53 pathway, activating mutations of NOTCH1, and dysfunctional...

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Topics

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Share to Clonal Evolution
Share to BCL2 gene
Share to NOTCH1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Mutation

Share to Receptor, Notch1

Share to Ribonucleoprotein, U2 Small Nuclear

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 25696844
DOI: 10.1182/asheducation-2014.1.119

Genes

NOTCH1
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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