Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial.

doi:10.1182/blood-2014-01-546150

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Article

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial.

Blood - 22 May 2014

Stilgenbauer Stephan, Schnaiter Andrea, Paschka Peter, Zenz Thorsten, Rossi Marianna, Döhner Konstanze, Bühler Andreas, Böttcher Sebastian, Ritgen Matthias, Kneba Michael, Winkler Dirk, Tausch Eugen, Hoth Patrick, Edelmann Jennifer, Mertens Daniel, Bullinger Lars, Bergmann Manuela, Kless Sabrina, Mack Silja, Jäger Ulrich, Patten Nancy, Wu Lin, Wenger Michael K, Fingerle-Rowson Günter, Lichter Peter, Cazzola Mario, Wendtner Clemens M, Fink Anna M, Fischer Kirsten, Busch Raymonde, Hallek Michael, Döhner Hartmut

Abstract excerpt

Mutations in TP53, NOTCH1, and SF3B1 were analyzed in the CLL8 study evaluating first-line therapy with fludarabine and cyclophosphamide (FC) or FC with rituximab (FCR) among patients with untreated chronic lymphocytic leukemia (CLL). TP53, NOTCH1, and SF3B1 were mutated in 11.5%, 10.0%, and 18.4% of patients, respectively. NOTCH1(mut) and SF3B1(mut) virtually showed mutual exclusivity (0.6% concurrence), but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24652989
DOI: 10.1182/blood-2014-01-546150

Genes

NOTCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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