Article

Gene Mutations and Treatment Outcome in Chronic Lymphocytic Leukemia: Results From the CLL8 Trial

2012-11-16

Abstract excerpt

Abstract Abstract 433 Novel gene mutations have been found in CLL by next generation sequencing including mutations of NOTCH1 and SF3B1 in 5–20% of cases. In initial studies, both have been associated with advanced disease and poor outcome. We assessed the incidence and impact of gene mutations in the CLL8 trial (1st line FC vs. FCR, n=817). TP53 (exons 2–11) was analyzed by a re-sequencing chip (Amplichip, Roche...

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Literature Corpus work: c3bebf00-6adb-5b83-963c-b22052ab7a70
DOI: 10.1182/blood.v120.21.433.433

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