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Article

Common variants in SCN10A gene associated with Brugada syndrome.

Human molecular genetics - 27 Dec 2021

Huang Yan, Chen Xiao-Meng, Barajas-Martinez Hector, Jiang Hong, Antzelevitch Charles, Hu Dan

Abstract excerpt

Genome-wide association studies indicate that SCN10A plays an important role in cardiac electrophysiology. Common and rare SCN10A variants are suggested to contribute to Brugada Syndrome (BrS), an inherited channelopathy resulting from genetic-determined loss-of-function in cardiac sodium channel. This study sought to characterize the role of SCN10A common variants in BrS. Clinical and genetic analyses were...

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Identifiers

PMID: 34312669
DOI: 10.1093/hmg/ddab217
PMCID: PMC8743002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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