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Article

Identification of a second GTP-bound magnesium ion in archaeal initiation factor 2.

Nucleic acids research - 11 Mar 2015

Dubiez Etienne, Aleksandrov Alexey, Lazennec-Schurdevin Christine, Mechulam Yves, Schmitt Emmanuelle

Abstract excerpt

Eukaryotic and archaeal translation initiation processes involve a heterotrimeric GTPase e/aIF2 crucial for accuracy of start codon selection. In eukaryotes, the GTPase activity of eIF2 is assisted by a GTPase-activating protein (GAP), eIF5. In archaea, orthologs of eIF5 are not found and aIF2 GT...

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Identifiers

PMID: 25690901
DOI: 10.1093/nar/gkv053
PMCID: PMC4357699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25690901-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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