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Article

Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.

Journal of molecular biology - 25 Sept 2009

Dev Kamal, Santangelo Thomas J, Rothenburg Stefan, Neculai Dante, Dey Madhusudan, Sicheri Frank, Dever Thomas E, Reeve John N, Hinnebusch Alan G

Abstract excerpt

Translation initiation is down-regulated in eukaryotes by phosphorylation of the alpha-subunit of eIF2 (eukaryotic initiation factor 2), which inhibits its guanine nucleotide exchange factor, eIF2B. The N-terminal S1 domain of phosphorylated eIF2alpha interacts with a subcomplex of eIF2B formed by the three regulatory subunits alpha/GCN3, beta/GCD7, and delta/GCD2, blocking the GDP-GTP exchange activity of the...

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Identifiers

PMID: 19616556
DOI: 10.1016/j.jmb.2009.07.030
PMCID: PMC2937263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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