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Article

The initiation of GTP hydrolysis by the G-domain of FeoB: insights from a transition-state complex structure.

PloS one - 1 Jan 2011

Ash Miriam-Rose, Maher Megan J, Guss J Mitchell, Jormakka Mika

Abstract excerpt

The polytopic membrane protein FeoB is a ferrous iron transporter in prokaryotes. The protein contains a potassium-activated GTPase domain that is essential in regulating the import of iron and conferring virulence to many disease-causing bacteria. However, the mechanism by which the G-domain of FeoB hydrolyzes GTP is not well understood. In particular, it is not yet known how the pivotal step in GTP hydrolysis...

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Identifiers

PMID: 21858085
DOI: 10.1371/journal.pone.0023355
PMCID: PMC3153494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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