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Article

The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation.

Molecular and cellular biology - 15 Aug 2018

Murakami Ryo, Singh Chingakham Ranjit, Morris Jacob, Tang Leiming, Harmon Ian, Takasu Azuma, Miyoshi Tomohiro, Ito Kosuke, Asano Katsura, Uchiumi Toshio

Abstract excerpt

Ribosomal stalk proteins recruit translation elongation GTPases to the factor-binding center of the ribosome. Initiation factor 5B (eIF5B in eukaryotes and aIF5B in archaea) is a universally conserved GTPase that promotes the joining of the large and small ribosomal subunits during translation initiation. Here we show that aIF5B binds to the C-terminal tail of the stalk protein. In the cocrystal structure, the...

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Identifiers

PMID: 29844065
DOI: 10.1128/MCB.00067-18
PMCID: PMC6066748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation.PMID 29844065Read ↗

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Interaction between 25S rRNA A loop and eukaryotic translation initiation factor 5B promotes subunit joining and ensures stringent AUG selection.Semantic proximity Read ↗

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eIF5A coordinates the transcription and translation of its target genesSemantic proximity Read ↗

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The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo.Semantic proximity Read ↗

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