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Article

Structural insights into the Switching Off of the Interaction between the Archaeal Ribosomal Stalk and aEF1A by Nucleotide Exchange Factor aEF1B.

Journal of molecular biology - 23 Jul 2021

Suzuki Takahiro, Ito Kosuke, Miyoshi Tomohiro, Murakami Ryo, Uchiumi Toshio

Abstract excerpt

The ribosomal stalk protein plays a crucial role in functional interactions with translational GTPase factors. It has been shown that the archaeal stalk aP1 binds to both GDP- and GTP-bound conformations of aEF1A through its C-terminal region in two different modes. To obtain an insight into how the aP1•aEF1A binding mode changes during the process of nucleotide exchange from GDP to GTP on aEF1A, we have analyzed...

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PMID: 33971210
DOI: 10.1016/j.jmb.2021.167046

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