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Article

Mechanism-independent optimization of combinatorial nanodiamond and unmodified drug delivery using a phenotypically driven platform technology.

ACS nano - 24 Mar 2015

Wang Hann, Lee Dong-Keun, Chen Kai-Yu, Chen Jing-Yao, Zhang Kangyi, Silva Aleidy, Ho Chih-Ming, Ho Dean

Abstract excerpt

Combination chemotherapy can mediate drug synergy to improve treatment efficacy against a broad spectrum of cancers. However, conventional multidrug regimens are often additively determined, which have long been believed to enable good cancer-killing efficiency but are insufficient to address the nonlinearity in dosing. Despite improved clinical outcomes by combination treatment, multi-objective combination...

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PMID: 25689511
DOI: 10.1021/acsnano.5b00638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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