Article

AI-guided design of a CXCR4-targeted core–shell nanocarrier for co-delivery of berberine/paclitaxel in cancer therapy

2025-08-14

Abstract excerpt

<title>Abstract</title> An integrated three-step artificial-intelligence (AI) workflow was used to accelerate the design of a CXCR4-targeted, dual-drug nanocarrier for colorectal-cancer therapy. First, the MD-Syn platform screened 38 approved oncology agents across six human colorectal-cancer cell lines (HCT116, HT29, LoVo, RKO, SW620, SW837) and identified paclitaxel (PTX) as the compound with a > 0.9999 prob...

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Literature Corpus work: db623cfe-30df-5177-957b-4fbc23cdf546
DOI: 10.21203/rs.3.rs-7307122/v1

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