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Article

Phenotypic response surface-guided pharmacotherapy for personalized combination treatment in complex diseases.

Expert opinion on pharmacotherapy - 1 Apr 2026

Khan Khalil Atif Ali, Saeed Akhtar Muhammad, Zaman Wajid, Amin Adnan, Ali Sajid

Abstract excerpt

INTRODUCTION: Optimizing multidrug regimens for complex diseases remains a major challenge in precision medicine because responses are shaped by interpatient heterogeneity, nonlinear drug interactions, and incomplete mechanistic knowledge. Phenotypic Response Surfaces (PRS) have emerged as a promising computational and translational framework for guiding pharmacotherapy by linking phenotypic information with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41992855
DOI: 10.1080/14656566.2026.2660981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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