Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy

Abstract excerpt

Significance A successful cancer therapy induces a strong antitumor response while causing minimal side effects. The heterogeneous nature of cancer observed across different regions of the primary tumor, across metastatic sites, across time, and across patients makes designing such a successful therapy challenging. Both standard of care and finely tailored treatment protocols run the risk of not exhibiting a...

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