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Article

A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association.

ACS chemical biology - 15 May 2015

Zhang Wei, Sankaran Saumya, Gozani Or, Song Jikui

Abstract excerpt

Recent studies have identified several genetic mutations within the BAH domain of human Origin Recognition Complex subunit 1 (hORC1BAH), including the R105Q mutation, implicated in Meier-Gorlin Syndrome (MGS). However, the pathological role of the hORC1 R105Q mutation remains unclear. In this study, we have investigated the interactions of the hORC1BAH domain with histone H4K20me2, DNA, and the nucleosome core...

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Identifiers

PMID: 25689043
DOI: 10.1021/cb5009684
PMCID: PMC4654454

Genes

ORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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