Article

Humanized <i>Drosophila</i> model of the Meier-Gorlin syndrome reveals conserved and divergent features of the Orc6 protein

2020-05-01

Abstract excerpt

Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder characterized by microtia, primordial dwarfism, small ears and skeletal abnormalities. Patients with MGS often carry mutations in the genes encoding the subunits of the Origin Recognition Complex (ORC), components of the pre-replicative complex (pre-RC) and replication machinery. Orc6 is an important component of ORC and has functions in both DNA r...

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Literature Corpus work: 0f6f150a-d363-5d83-8d52-7dbd1e930870
DOI: 10.1101/2020.04.29.068866

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