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Article

Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements.

eLife - 17 Feb 2015

Ellison Christopher E, Bachtrog Doris

Abstract excerpt

Transposable elements (TEs) allow rewiring of regulatory networks, and the recent amplification of the ISX element dispersed 77 functional but suboptimal binding sites for the dosage compensation complex to a newly formed X chromosome in Drosophila. Here we identify two linked refining mutations within ISX that interact epistatically to increase binding affinity to the dosage compensation complex. Selection has...

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Share to DNA Transposable Elements
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Conversion

Share to Mutagenesis, Insertional

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Share to Regulatory Sequences, Nucleic Acid

Source

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Identifiers

PMID: 25688566
DOI: 10.7554/eLife.05899
PMCID: PMC4384637

Genes

ISX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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