Article
Analysis of epigenetic stability and conversions in Saccharomyces cerevisiae reveals a novel role of CAF-I in position-effect variegation.
Nucleic acids research - 1 Oct 2013
Jeffery Daniel C B, Wyse Brandon A, Rehman Muhammad Attiq, Brown Geoffrey W, You Zhiying, Oshidari Roxanne, Masai Hisao, Yankulov Krassimir Y
Abstract excerpt
Position-effect variegation (PEV) phenotypes are characterized by the robust multigenerational repression of a gene located at a certain locus (often called gene silencing) and occasional conversions to fully active state. Consequently, the active state then persists with occasional conversions to the repressed state. These effects are mediated by the establishment and maintenance of heterochromatin or...
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