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Article

Ancestral Chromatin Configuration Constrains Chromatin Evolution on Differentiating Sex Chromosomes in Drosophila.

PLoS genetics - 1 Jun 2015

Zhou Qi, Bachtrog Doris

Abstract excerpt

Sex chromosomes evolve distinctive types of chromatin from a pair of ancestral autosomes that are usually euchromatic. In Drosophila, the dosage-compensated X becomes enriched for hyperactive chromatin in males (mediated by H4K16ac), while the Y chromosome acquires silencing heterochromatin (enriched for H3K9me2/3). Drosophila autosomes are typically mostly euchromatic but the small dot chromosome has evolved a...

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Identifiers

PMID: 26114585
DOI: 10.1371/journal.pgen.1005331
PMCID: PMC4482674

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