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Article

Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension.

Nature communications - 17 Feb 2015

Kumarasamy Sivarajan, Waghulde Harshal, Gopalakrishnan Kathirvel, Mell Blair, Morgan Eric, Joe Bina

Abstract excerpt

Genome-wide association studies (GWAS) have prioritized a transcription factor, nuclear receptor 2 family 2 (NR2F2), as being associated with essential hypertension in humans. Here we provide evidence that validates this association and indicates that Nr2f2 is a genetic determinant of blood pressure (BP). Using the zinc-finger nuclease technology, the generation of a targeted Nr2f2-edited rat model is reported....

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Identifiers

PMID: 25687237
DOI: 10.1038/ncomms7252
PMCID: PMC4486351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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