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Article

Impairment of the Hypothalamus-Pituitary-Thyroid Axis Caused by Naturally Occurring GATA2 Mutations In Vitro.

International journal of molecular sciences - 16 Sept 2021

Sakai Yuki, Ohba Kenji, Sasaki Shigekazu, Matsushita Akio, Nakamura Hiroko Misawa, Kuroda Go, Tsuriya Daisuke, Yamashita Miho, Suda Takafumi

Abstract excerpt

The transcription factor GATA2 regulates gene expression in several cells and tissues, including hematopoietic tissues and the central nervous system. Recent studies revealed that loss-of-function mutations in GATA2 are associated with hematological disorders. Our earlier in vitro studies showed that GATA2 plays an essential role in the hypothalamus-pituitary-thyroid axis (HPT axis) by regulating the genes...

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Identifiers

PMID: 34576178
DOI: 10.3390/ijms221810015
PMCID: PMC8467656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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