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Article

Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction.

Human molecular genetics - 1 Jun 2010

Yamanaka Tomoyuki, Tosaki Asako, Miyazaki Haruko, Kurosawa Masaru, Furukawa Yoshiaki, Yamada Mizuki, Nukina Nobuyuki

Abstract excerpt

In polyglutamine diseases including Huntington's disease (HD), mutant proteins containing expanded polyglutamine stretches form nuclear aggregates in neurons. Although analysis of their disease models suggested a significance of transcriptional dysregulation in these diseases, how it mediates the specific neuronal cell dysfunction remains obscure. Here we performed a comprehensive analysis of altered DNA binding...

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Identifiers

PMID: 20185558
DOI: 10.1093/hmg/ddq087
PMCID: PMC2865370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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