Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2010

Oishi Yumiko, Manabe Ichiro, Imai Yasushi, Hara Kazuo, Horikoshi Momoko, Fujiu Katsuhito, Tanaka Toshihiro, Aizawa Tadanori, Kadowaki Takashi, Nagai Ryozo

Abstract excerpt

Krüppel-like factor 5 (KLF5) is a zinc-finger-type transcription factor that mediates the tissue remodeling in cardiovascular diseases, such as atherosclerosis, restenosis, and cardiac hypertrophy. Our previous studies have shown that KLF5 is induced by angiotensin II (AII), although the precise molecular mechanism is not yet known. Here we analyzed regulatory single nucleotide polymorphisms (SNPs) within the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin II
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to MADS Domain Proteins

Share to MEF2 Transcription Factors

Share to Myogenic Regulatory Factors

Share to p38 Mitogen-Activated Protein Kinases

Share to Response Elements

Source

Identifiers

PMID: 20086047
DOI: 10.1096/fj.09-146589

Genes

KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension.PMID 20086047Read ↗

KLF5/BTEB2, a Krüppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy.Semantic proximity Read ↗

KLF15 Loss-of-Function Mutation Underlying Atrial Fibrillation as well as Ventricular Arrhythmias and Cardiomyopathy.Semantic proximity Read ↗

Role of Krüppel-Like Factor 4 and its Binding Proteins in Vascular DiseaseSemantic proximity Read ↗

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.Semantic proximity Read ↗

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).Semantic proximity Read ↗

Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.Semantic proximity Read ↗

Epigenetic derepression of FKBP5 by aging and stress contributes to NF-ĸB-driven inflammation and cardiovascular riskSemantic proximity Read ↗

Molecular genetic study on GATA5 gene promoter in acute myocardial infarction.Semantic proximity Read ↗

Klf15 Deficiency Is a Molecular Link Between Heart Failure and Aortic Aneurysm FormationSemantic proximity Read ↗

FHL5 controls vascular disease-associated gene programs in smooth muscle cellsSemantic proximity Read ↗

Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic PotentialSemantic proximity Read ↗

Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.