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Article

The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation

29 Jul 2002

Abstract excerpt

Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1alpha through its competitive binding with HIF-1alpha to CBP/p300. Disruption of the gene encoding Cited2 is embryonic lethal because of defects in the development of heart and neural tube. Morphological and Doppler echocardiographic analyses of...

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Identifiers

PMID: 12149478
DOI: 10.1073/pnas.162371799

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Related research

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The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulationPMID 12149478Read ↗

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CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expressionSemantic proximity Read ↗

Identification and functional analysis of CITED2 mutations in patients with congenital heart defects.Semantic proximity Read ↗

Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency.Semantic proximity Read ↗

Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis.Semantic proximity Read ↗

CITED2 is a Conserved Regulator of the Uterine-Placental InterfaceSemantic proximity Read ↗

CITED2 Mutations in Conserved Regions Contribute to Conotruncal Heart Defects in Chinese ChildrenSemantic proximity Read ↗

A novel NR2F2 loss-of-function mutation predisposes to congenital heart defect.Semantic proximity Read ↗

Missense mutations in the CITED2 gene may contribute to congenital heart disease.Semantic proximity Read ↗

Functional significance of SRJ domain mutations in CITED2.Semantic proximity Read ↗

Loss of Cited2 causes congenital heart disease by perturbing left–right patterning of the body axisSemantic proximity Read ↗

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